Case Control Study - 961 Words

Discussion In recent years, it has been suggested that miRNAs act as key regulators of gene expression networks. Like other genes, single nucleotide polymorphism in miRNA genes can affects their function at different levels, such as miRNA transcription, maturation and target specificity. Our study is the first report of mir 23a, mir155 and mir 196a2 polymorphism in the iranian MS patients. In this case control study we examined the impact of functional mir 155 rs767649, mir196a2 rs11614913 and miR-23a rs3745453 polymorphism on MS risk in a sample of Isfahan population. We found that miR-23a rs3745453 CT variant seem to increase the risk of MS in this population (OR =2.5). Compared with ridolfi et al. The results did not support an†¦show more content†¦Saumet et al. in 2008 observed that miR-23a~27a~24-2 is directly repressed by the PML-RARA oncogene. also in some study upregulation of miR-23a has been observed in cancers(22). Considerable up-regulation of miR-23a was reported by Meng and Gottardo in human bladder cancer and in malignant cholangiocytes compared to normal tissues. Furthermore, Mi et al. in their study showed that miR-23a was among several other miRNAs that have been differentially expressed between acute myeloid leukemia (AMLs) and acute lymphoblastic leukemia (ALLs). In addition, up-regulation of miR-23a/b along with miR-24 has also been identified in osteoblast cell line (20,21). An exonic MiR-155 with rs767649 (T/A) polymorphism in the upstream region of the pre-miR-155 gene is transcribed from the B-cell integration cluster (BIC) that is located on chromosome 21. It has been suggested that miR155 modulate host antiviral immune response by elevating type I IFN signaling. In some study This miRNA proposed to be involved in diverse biological processes, such as inflammation, differentiation, and immunity. Furthermore, dysregulation of miR-155 has been reported in viral infections and different cancers. Some study reported mir155 highly expressed in activated T and B cells as well as macrophage and dendritic cells(23). Our result suggested that rs767649 TT genotype have potential to act as a risk factor for MS(OR=2.5), also 94 % ofShow MoreRelatedFatty Acid Composition Of Adipose Tissue And Colorectal Cancer : A Case Control Study845 Words   |  4 PagesFatty acid composition of adipose tissue and colorectal cancer: a case-control study Colorectal cancer is considered as the third most common cancers worldwide that usually leads to the death of the patient. Studies have proved that lifestyle factors great influence the development and spread of cancer. Modifying the lifestyle can reduce the risk of getting colorectal cancer by 70%. It is noted that more consumption of red and processed meat increase the risk of developing colorectal cancer. HoweverRead MoreA Study On Sudden Infant Death Syndrome1664 Words   |  7 PagesBackground Information: The study took place in north Europe Scandinavian countries such as Denmark, Norway and Sweden. The local paediatrician from Norway and Sweden and the forensic institution of Denmark invited parents of sudden infant death syndromes (SIDS) to take part in the study. Sudden infant death syndrome is the sudden, unexpected and unexplained death of an apparently healthy baby. There were several aims behind the study. The main aim of the study was to overlook whether smoking wasRead MoreUnderestimated Due With An Inadequate Surveillance System1683 Words   |  7 Pagesthe increase in surveillance and intervention in both cases is the advancement in technology and increase in mobility of modern times and globalization. As a result of this, American economic stimulation in the Caribbean demanded surveillance increases; the possibility of travel by EHF victims/contacts from West Africa caused hysteria in the Western world and stimulated intervention from world and American health care authorities. 2. A case study outline for salmonellosis involves the identificationRead MoreDepression And Dementi Depression1276 Words   |  6 PagesSeveral studies have shown links between depression and dementia. Brommelhoff, Johansson, Fratiglioni, Gatz, McArdle, Pederson state, â€Å"there are three hypotheses that might explain the association† (Jorm, 2001). The first is that depression is a symptom that indicates the onset of dementia, also known as a prodromal feature. The second is that the two are independent illnesses; however, depression causes cognitive deficits, which lead to an earlier onset of dementia. The last argues that depressionRead MoreThe Association Between Low Hdl Blood Levels And Colonic Cancer1648 Words   |  7 PagesDyslipidemia is a pathological alteration of lipid and lipoprotein concentrations in the blood. It is one of the main elements of metabolic syndrome. Epidemiological studies have shown that persons with the metabolic syndrome have an increased r isk of colorectal cancer (CRC). One of the possible mechanisms is that lipids and lipoproteins have been found to be associated with neoplastic processes as well as inflammation, insulin resistance and oxidative stress. On the other side, some of the factorsRead MoreHuman Searches Of Databases Produced A Total Of 704 References And Abstract Records After Removal Of Duplicates.we Accessed 18967 Words   |  4 Pagespapers for further full text screening to determine eligibility. We found 1 ongoing study (Badlani 2009) and four studies (Hajebrahimi 2011; Lee 2011; Xu 2007; Yamanishi 2004) fulfilled the inclusion criteria. A flow diagram of the process of selecting studies is presented in Figure 1. Included studies    A total of 322 females with VD in four trials were randomly allocated to pharmacological interventions or control groups. In Hajebrahimi 2011, 40 females diagnosed with VD according to AUASS andRead MoreA word related presentation happens throughout the execution of occupation obligations and may put900 Words   |  4 Pagesis a vital device in danger evaluation and in the administration of exercises including treatment of risky substances.[1] There are numerous perilous substances for which there are no formal word related presentation limits. In these cases, danger banding or control banding methods might be utilized to guarantee safe handling.simple representation of presentation danger appraisal and administration progressive system focused around accessible data Word related Introduction Limits (Oels) have beenRead MoreEvidence Based Practice Worksheet On Patient Care1067 Words   |  5 Pagesenteral nutrition therapy. Results of two retrospective studies determined that by the 45th week of enteral nutrition administration, 85% of patients reached remission when compared to only 76% of remission in patients who were receiving an oral route of nutrition intake. However, all of the patients examined did exhibit a decrease in severity of the disease (P0.0001). Additionally, the Children’s Hospital of Philadelphia reported a retrospective study determined that 65% of 23 patients reporting withRead MoreViewing Cute Images Increases Behavioral Carefulness1370 Words   |  6 Pagesthem to use tweezers to remove plastic body parts without touching the sides of the compartments. The game served as an assessment of behavioral carefulness. Participants exposed to cute infant animals displayed greater improvements in fine-motor control from before to after the slide show. Lack of consistent changes in physiological measures ruled out general physiological arousal as an explanation. Results indicated that cuteness not only motivates people to nurture, but also enhances their abilityRead MoreEssay about Its Time To Make Marijuana Legal for Recreational Use 923 Words   |  4 Pa gesharmless to the adult user. Several studies have concluded that even long-term use of marijuana is not associated with an increased cancer risk. This includes cancers of the lungs, prostate, breasts, or cervix among others under current study. A recent population-based case-control study in 2009 even found that light marijuana usage over a 20 year period was associated with a lowered risk of head and neck cancer, and a 5-year-long population-based case control study found that even long-term heavy marijuana

Its Time for Open Adoption Essay - 1087 Words

Its Time for Open Adoption Based on statistics gathered by the United States Department of Health and Human Services Childrens Bureau, approximately 46,000 children found homes through the foster care system last year alone (Cumpston, 8b). It is hard to imagine that there is this unbelievable number of children adopted in just one year, and the process is still different for every family who goes through it. Only after much research, can one conclude that while handling an adoption, a process known as open adoption is the most beneficial for everyone alike. There are essentially two ways to adopt a child; one technique, known as an open adoption and one known as closed. Throughout the first quarter of the century,†¦show more content†¦As a result of the birth parents and the adoptive parents maintaining contact with each other, the adoptee is able to ask questions pertaining to why s/he was put up for adoption and consequently can better understand the events leading to the situation. This helps to wave a portion of the feelings of abandonment, common to many children after an adoption. Otherwise the sense of abandonment will more than likely carry over into the adult life and affect the way that person handles stressful situations (Open Adoption). Additionally, the adoptee will have access to background information readily provided by the birth parents, thus eliminating countless searches by the child when s/he is older. Many adopted children chase after their true identity their whole lives, in turn not finding anything but a few measly pictures or letters (Baran, p 235). In all reality, it makes sense that a mother who knows where her child is going, with whom, and in what kind of environment, will be, at the very least, relieved of a small amount of apprehension. In most cases, prior to the adoption, a legal document will be written up, agreed upon and signed by both sets of parents, therefore describing the extent of contact by the birth mother with the child.Show MoreRelatedAdoption Is A Important For Children994 Words   |  4 Pages Adoption Adoption is a practice that is as old as time. It was spoken of in the Bible and has been proven as a successful way to make sure unwanted children get a home and family. Adoption can be a positive experience for those who cannot have a child and want to provide a loving environment. There are some who feel that people should take responsibility for their actions if they have the child. While I do agree with accountability, sometimes being a parent is realizing when the better option forRead MoreEssay about The Advantages of Closed Adoption Over Open Adoption1092 Words   |  5 Pageswho I am. My whole life is messed up. It’s not my fault. It can’t be fixed,† said a girl adopted into an open adoption (Byrd). An open adoption is a process in which the birth parents and the adoptive parents know each other and are involved in the adopted child’s life. A closed adoption is when there is no contact at all and no identifying information is given between birth and adoptive parents (Byrd). While both are common to today’s society, closed adoptions allow opportunities for the adoptiveRead MoreAdoptees Have The Right Of Original Birth Certificates1086 Words   |  5 Pagesquestions, because of equality issues, and because of the doors it opens to adoptees that have empty holes in their history. First, adoptees have the right to have access to original birth certificates because they have questions. Questions about their health, questions about who they came, who they got their blue eyes from, and other such things. As Melinda Elkins Dawson, one of 200 newborns relocated to other states for adoption in Georgia in the 50’s and 60’s says, â€Å"Every adopted child has questionsRead MoreClosed Adoption : A New Home864 Words   |  4 PagesClosed Adoption About twenty years ago my Uncle Hosea had a son named Javion. He was the first boy out of all the girls my uncle had conceived, which made him very proud. However, due to some underlying circumstances, he was taken away from his mom and put into the system. He was somehow adopted and never seen again, nor has any information been given out to our family to help locate him. He had entered closed adoption, which is an irreversible system where parents give up their rights to know anyRead MoreEssay about Arguments for Open Adoption Records1721 Words   |  7 PagesFor those who are a part of the adoption world one of the most hotly debated issues is whether birth records should be open or closed to adoptees. With this issue comes strong feelings on both sides. In most states adoption records are fully sealed and inaccessible, unless the adoptee petitions the court. In 16 states these records are fully or partially available upon request with no court involvement, and also may depend u pon when you were born. In a few states records are completely prohibitedRead MoreEssay on Why Should Abortion be illegal?659 Words   |  3 Pages Abortion is taking the life of a new human being. Many people would say that it’s not human to kill another person but what makes abortion any different from that? The main reason why many women abort is because they’re too young and are scared of the impact a baby will make in there life, they don’t have enough money to support a child, or their relationship starts failing after finding out they’re pregnant. As a Christian I was taught that abortion is wrong and that only God can determine whoRead MoreOptions Other than Abortion Essay978 Words   |  4 Pagesabortion is one of many solutions to get rid of a baby that is not wanted or it’s not the right time to raise a baby; it is also one of the most controversial issues of our time. Abortion has it’s own effects on people and society mostly i n a bad way. Church and other religious groups are against abortion, while others in our society are supporters. There are some options other than abortion to solve this issue, such as: adoption, teen parenting, and more. â€Å"How many more women will be exploited, injuredRead MoreAdoption and Parent775 Words   |  4 Pagesthousand adoption cases take place each year. Adoption is the practice where the rights of biological parent(s) to the child are transferred to foster parent(s) permanently. Adoption of a child usually would take place at a tender age of the child’s life, so the child wouldn’t know of ever being adopted. Although this depends on if the child’s foster parents reveals to them the information of them being adopted. Usually a biological parent putting their child in foster care or up for adoption is allRead MoreAbortion Persuasive Essay755 Words   |  4 Pagesa chance at life. Adoption is one of these safe solutions. Kristi Burton Brown stat ed â€Å" In the USA, there are approximately two million infertile couples waiting to adopt†¦Ã¢â‚¬  The child that is considered a â€Å"mistake† could be the miracle that a couple has been waiting for. Adoptions can cost an enormous amount of money, however it proves that these families are not in it for the money, instead they are in it because they have waited to hold a baby that they can call theirs. Adoption is full of differentRead MorePersuasive Essay On Adoption1100 Words   |  5 PagesAdoption Adoption is a process whereby a person assumes the parenting of another, usually a child, from that persons biological or legal parent, and in so doing, permanently transfers all rights and responsibilities, from the biological parent or parents. Unlike guardianship adoption effect a permanent change in status and as such requires societal recognition. Adoption is a good process which helps children in different ways. I prefer to handle adoption worldwide and in all societies

Othello Iago Essay Example For Students

Othello Iago Essay Iago has no conscience. He is an angry man and is happy to take down everyone around him to get what he wants: revenge. It is in Act 1, Scene 3, that he devises his evil plan. Here we can see inside Iago’s mind. It is easy to see that his primary motivation is jealousy: jealousy that Othello may have slept with his wife, and jealousy that Othello chose Cassio over him. As he plots his revenge, it is clear Iago respects and cares for no one. (Act 1, Scene 3, 378-381)I hate the Moor,And it is thought abroad that twixt my sheetsH’as done my office. I know not if’t be true,But I, for mere suspicion in that kind,Will do, as if for surety. Iago states here he suspects Othello may have slept with his wife. He is not sure of this, but declares that surety is not necessary. I believe Iago is not so much concerned with his wife being unfaithful, but that he can’t stand the thought that it may have been with Othello. (Act 1, Scene 3, 381-382)He holds me well;The better shall my purpose work on him. This shows how conniving Iago is. He will use the fact that Othello trusts him to get his revenge. (Act 1, Scene 3, 383-385)Cassio’s a proper man. Let me see now;To get his place, and to plume up my willIn double knavery. How? How? Let’s see. Here â€Å"double knavery† means to pull off one stunt and obtain two desired outcomes to get Cassio’s position (which he felt he deserved) and to make himself appear respectful for his ego’s sake. Another benefit of getting Cassio’s position is he can be closer to Othello. When he accomplishes this, he will be able to obtain even more trust from Othello and begin manipulating him to believe that Cassio and Desdemona are having an adulteress relationship:(Act 1, Scene 3, 386-389)After some time, to abuse Othello’s earsThat he is too familiar with his wife. He hath a person and a smooth disposeTo be suspected framed to make women false. Iago knows that Othello is a man of integrity and therefore, believes others to be so until proven differently. Iago has no respect for integrity and consequently, has no respect for Othello. This is obvious in his reference to Othello as an â€Å"ass† which can â€Å"tenderly be led by th’ nose.†(Act 1, Scene 3, 390-393)The Moor is of a free and open natureThat thinks men honest that but seem to be so;And will as tenderly be led by th’ noseAs asses are. One of the frightening things about Iago is that he takes what most of us see as good and uses those traits against them. There are several examples in this soliloquy. One example is when he refers to Cassio being a â€Å"proper† man. Proper means handsome in this context. Being handsome is positive but Iago will use Cassio’s handsomeness to evoke jealousy in Othello. Women are attracted to Cassio. Already amazed Desdemona â€Å"chose him,† a large, black scarred man, not conventionally handsome at all, it will be easy to convince Othello that Desdemona might be attracted to Cassio. Another example is that Iago will use Othello’s trustfulness and integrity. Iago knows Othello already trusts him. Iago will â€Å"play† an honest man who is loyal and loves his general. If this is the case, why would Othello believe for a minute that Iago is not telling him the truth?With this, revenge comes easy for Iago.

Rebecca By Du Maurier Essays - English-language Films,

Rebecca By Du Maurier As Daphne du Maurier finished her novel, she said to herself, "So it was. A finished novel. Title, Rebecca. I wondered if my publisher would think it stupid, overdone. Luckily (for me) he did not. Nor did the readers when it was published." Little did du Maurier know, her novel ended up becoming a great success. Soon after, Alfred Hitchcock made a film version of Rebecca that soon became an even greater success than the novel itself. There are many opinions as to which version is more effective. I believe that the novel was far more effective that the movie version for a number of reasons. One of the reasons that I feel that the original novel Rebecca was more effective than the movie version was that I think the novel held suspense in a better way. While reading the novel, my suspense was able to build up more and more as I read further on. The plot seemed to move slowly, without revealing too much information very quickly. It gave me a chance to think for myself what I thought would happen next, which got my imagination working. When watching the movie, I found that each event happened too quickly, which didn't give me much of a chance to think about what was going on. One example of this is when Rebecca's boat was discovered. In the novel, each event that happened during that time was explained slowly. Much detail was given and as I read on, my suspense was able to build up while I was waiting to find out what had really happened. In the movie, the events during that time went very quickly, and the information was just thrown at you and then it was over. Also, during the movie, the events kept on happening without any pause which didn't give you time to think, let alone gather up the information given. In the novel, one important event would happen, giving more information, and then the plot would slow down a bit, allowing me to gather my thoughts and form and idea of what I thought would happen next. Another reason why I thought the novel was more effective than the movie was that the movie didn't go into as much detail as the novel did. In the novel, every part of the plot was explained into such detail that I could imagine everything almost to the point that I felt I was right there in the story. Each and every character was explained so well that I could actually see them in my mind. One example of this is when du Maurier explained what Mrs. Davners was like. She was described with such an evil sense of passion that it actually sent a chill up my spine and I was able to feel a dark presence about the story every time her name was mentioned. In the movie, the plot moved very quickly and nothing went into much detail. The characters didn't have much significance because nothing was really told about them except from what you learned from the initial plot of the story. The last reason why I believe the novel to be more effective than the movie version of Rebecca is that the novel is able to get my imagination working more effectively. During the novel, things move slowly giving you time to form your own thoughts as to what is happening. The novel also takes more time and hints at things before giving the actual information about the truth to the whole story. This allowed me to use my imagination and add on to what I already knew about the story and then come up with my own idea of what I thought was going to happen. The best example of this is when Maxim was throwing the costume ball. While the protagonist, Mrs. de Winter, was trying to think of a costume, and then Mrs. Davners gave her the idea to use the white gown from the picture of Caroline de Winter, there were little hints that made me realize that there was something that wasn't being told. I thought it to be very unlikely that Mrs. Davners would help Mrs. de Winter, so I came to the conclusion that something bad was going to come of the whole situation. I was able to use my imagination and form my own ending to the situation. While watching the movie, I wasn't given the time or the pauses to allow me